Women’s Hormones and Aging Research Program (WHARP) is a clinical and translational research group that aims to advance our understanding and treatment of symptoms resulting from estrogen withdrawal in the brain.  This includes affective disturbance, sleep disruption, hot flashes, and cognitive performance.  We study the biological basis of these symptoms as well as their interactions and strategies for optimizing treatment in healthy women during the menopause transition, women undergoing anti-estrogen therapy for breast cancer, and using experimental paradigms.