Director of Research
Hadine Joffe, MD, MSc, is the Executive Director of the Mary Horrigan Connors Center for Women’s Health and Gender Biology and Vice Chair for Research in the Department of Psychiatry at Brigham and Women’s Hospital. She was recently appointed as the Paula A. Johnson Associate Professor of Psychiatry in the Field of Women’s Health at Harvard Medical School. With joint positions at Brigham and Women’s Hospital and Dana-Farber Cancer Institute, Dr. Joffe also directs the Women’s Hormones and Aging Research Program, which is dedicated to advancing the understanding and treatment of symptoms resulting from reproductive hormone changes in the brain. Her clinical and research work is focused on the course, mechanisms, and treatment of menopausal symptoms – including hot flashes, sleep disturbance, depression, and fatigue – in healthy women and in breast cancer patients. An experienced clinician and NIH-funded researcher in women’s mental health, she is also studying the effects of reproductive hormones on mood, as well as the reproductive and metabolic consequences of psychotropic medications. Dr. Joffe received her medical degree from Cornell University Medical College. She completed residency training in Psychiatry at McLean Hospital and a fellowship in Reproductive Psychiatry at Massachusetts General Hospital. In recognition of her contributions to women’s health research, she was awarded the Thomas Clarkson Outstanding Clinical & Basic Science Research Award from the North American Menopause Society.
For a complete list of Dr. Joffe's publications, please click here.
Dr. Harder is a neuropsychiatrist with an interest in inflammation, autoimmune disorders, and neuropsychiatric disturbance. She obtained her medical degree from Weill Cornell Medical College, completed her residency in psychiatry at the Harvard Longwood training program, and her fellowship in Behavioral Neurology and Neuropsychiatry at Brigham and Women’s Hospital. She is the principal investigator on a randomized controlled trial of salicylic acid as an augmenting agent for treatment-resistant depression, as well as co-investigator on a trial of an IL-6 receptor antagonist for the treatment of depression. She is currently working with Dr. Joffe on a study of premenstrual inflammatory markers and their association with depression.
Dr. Meyer is a consultation-liaison psychiatrist specializing in psycho-oncology, particularly women's cancers. Her current research focuses upon characterizing risk factors and interventions for fatigue, cognitive dysfunction, and depression in cancer patients. She is the principal investigator on a RCT assessing the effect of naltrexone on treatment-emergent fatigue during radiation therapy for breast cancer and is a co-investigator on Dr. Joffe's study assessing predictors of hot flashes on adjuvant endocrine therapy for breast cancer.
Dr. Mittal is an Instructor in Psychiatry at Harvard Medical School and the Director of Reproductive Psychiatry Consultation in the Department of Psychiatry at BWH. She currently provides inpatient and outpatient psychiatry consultations at BWH. She obtained her medical degree from the University of Maryland School of Medicine, residency training in the Harvard Longwood Psychiatry Residency Training Program, and a fellowship in Psychosomatic Medicine at BWH. Her clinical interests include substance use and its treatment during pregnancy, as well as the mental health care of women with high risk pregnancy and with babies admitted to the neonatal intensive care unit. Dr. Mittal sees outpatients in a co-located clinic within the Maternal Fetal Medicine practice and is a consulting psychiatrist for McPAP for Moms.
Dr. Nathan joined the Women’s Hormone and Aging Research Program in July 2016 as a clinical and research fellow and as junior faculty in July 2017. Prior to this she completed medical school at the University of Maryland School of Medicine and her adult Psychiatry Residency training at the Johns Hopkins Hospital. During her last year she served as chief resident. She has a particular interest in mood disorders and is hoping to pursue a career in academic psychiatry.
Dr. Taylor joined WHARP in July 2017 as a co-investigator on Dr. Joffe’s protocols investigating sleep disturbance during menopause. He completed his MD, MPH, and residency in psychiatry at Johns Hopkins University where he served as chief resident in his last year. He is currently a fellow working with the Broad Institute helping to develop tools for collecting phenotypic data in large-scale psychiatric genetic studies. He has a particular interest in mood disorders, substance-use disorders and non-substance related disorders of motivated behavior.
Aleta joined the Women's Hormones and Aging Research Program in late 2015 as the Project Manager. She completed her MPH in Epidemiology from Boston University School of Public Health, her MS in Conservation Biology & Sustainability from the University of Maryland-College Park, and her BA in Psychology from the University of Chicago. Before joining WHARP, Aleta worked for the Nurses' Health Study at Brigham & Women's Hospital and for the Department of Pediatrics at Boston Medical Center. She also completed a practicum at Slone Epidemiology Center for PRESTO, an Internet-based fertility cohort study. She is interested in studying women's mental and reproductive health and investigating quality-of-life outcomes for women across the lifespan.
Clinical Research Coordinators
Kathleen joined the Women’s Hormones and Aging Research Program in June 2016 as a Research Coordinator. She graduated from Cornell University with a BS in Human Development, where she worked as a Research Assistant for two years in the Adolescent Transitions Laboratory. Her research interests focus on the biological and social factors that impact the onset and maintenance of depression in women throughout the lifespan. She plans to pursue a PhD in clinical psychology.
Moira joined the Women’s Hormones and Aging Research Program in January 2018 as a Research Coordinator. She studied psychology and sociology at American University where she obtained her BA and gained research experience at the NIH. Her interests include Psycho-Oncology, specifically within women. She hopes to pursue a PhD in clinical psychology.
Julia joined the Women’s Hormones and Aging Research Program in May 2017 as a Research Coordinator. She graduated from Tufts University with a BA in Clinical Psychology, where she worked at the PTSD Neuroimaging Laboratory, and spent a year as a Student Researcher at McLean Hospital in the Child and Adolescent Mood Disorders Lab. She plans to pursue a PhD in Clinical Psychology.
Phoebe joined the Women’s Hormones and Aging Research Program in November 2017 as a Research Trainee. She completed her BS in Biology & Psychology at The University of South Carolina-Columbia, where she worked as an undergraduate Medical Intern in the Emergency Unit at Palmetto Health-Richland. Her research interests include exploring the effects of psychological distress on physiology over time, as well as the relationship between combined treatment methods and quality of life outcomes. She plans to pursue a degree in medicine.
Anouk is enrolled in a combined MD/PhD training program at the University of Groningen in the Netherlands and is on the research team for the Netherlands Study of Depression and Anxiety (NESDA). For her doctoral research, in collaboration with WHARP at Brigham & Women's Hospital, where she will be based in 2019, she will focus her thesis on female sex hormones. She is especially interested in the role of female and male sex hormones in mood.
Dr. Freid is a clinical psychologist in private practice. She consults to WHARP on issues related to mental health assessments and is a Lecturer in Psychiatry at Harvard Medical School. She received her Ph.D. in clinical psychology from Vanderbilt University, completed her predoctoral internship at the University of Chicago Medical Center and postdoctoral training at the Boston University Center for Anxiety and Related Disorders. After completing her training, Dr. Freid worked at McLean Hospital managing a multi-site R01 investigating treatment for women with substance use disorders and then served as the WHARP Project Manager. Dr. Freid is interested in the assessment of and empirically supported treatments for anxiety, depression and eating disorders and common factors among these disorders that can be targeted in treatment.
Current Research Collaborators
Dr. Joffe and all the faculty working with WHARP are proud to collaborate with leaders in a diversity of fields, including sleep medicine, cardiovascular physiology, endocrinology, breast oncology, and psychiatry.
Physical/Clinical Investigator, General Medicine & Primary Care, Department of Medicine, Beth Israel Deaconess Medical Center
Instructor in Medicine, Harvard Medical School
Chief, Division of Sleep Medicine, Massachusetts General Hospital
Director, Sleep Laboratory, Massachusetts General Hospital
Assistant Professor of Neurology, Harvard Medical School
Associate Physician in Medicine, Massachusetts General Hospital
Associate Chief, Reproductive Endocrine Unit, Massachusetts General Hospital
Professor of Medicine, Harvard Medical School
Founder and Director, Program for Young Women with Breast Cancer, Dana Farber Cancer Institute
Director, Adult Survivorship Program, Dana Farber Cancer Institute
Senior Physician, Breast Oncology Center, Dana Farber Cancer Institute
Associate Professor of Medicine, Harvard Medical School
Director, Cardiovascular Research Laboratory, Spaulding Rehabilitation Hospital
Associate Professor, Department of Physical Medicine & Rehabilitation, Harvard Medical School
Staff Psychologist, Psychosocial Oncology, Dana Farber Cancer Institute
Instructor in Pediatrics, Harvard Medical School
Collaborations with National Networks
The Study of Women's Health Across the Nation (SWAN) is a multi-site longitudinal, epidemiologic study designed to examine the health of women during their middle years. The study examines the physical, biological, psychological and social changes during this transitional period.
WHARP Lab Alumni
Catharine joined the Women’s Hormones and Aging Research Program for the summer of 2017 as a Research Trainee. A rising senior at Wellesley College, Catharine is majoring in Psychology with a minor in Economics and a concentration in Spanish. At Wellesley, she conducted a research project on the effects of bilingualism on task-switching ability and works as a research assistant in a Psychology lab focusing on memory loss in amnesia patients. She plans to continue this work with a thesis on memory loss and moral decision making.
Katie was a Clinical Research Coordinator for WHARP from 2015-2017 where she coordinated subject visits and data collection for multiple studies, assisted with several grant submissions, and presented posters at annual research events for the Brigham & Women's and Harvard Psychiatry communities. She graduated from Washington University in St. Louis in 2015 with a BA in Philosophy-Neuroscience-Psychology, and is starting an MD/MPH program at Brown University in August 2017.
Akanksha joined WHARP from June to December 2016 as a Research Trainee. As a junior at Boston University, where she was double majoring in Psychology and Biology with a specialization in cell biology, molecular biology and genetics, Akanksha assisted with a research project looking at stress responses in women with and without hot flashes. Akanksha’s research interests are in women’s reproductive health and neuroendocrinology, and she intends to pursue an MD after graduating from BU.
Julie was a Clinical Research Coordinator for WHARP from 2014-2016 where she helped to complete recruitment for an NIH R01 grant investigating the effects of hormones on mood in menopause and to launch recruitment for two new studies: one looking at stress response in women with and without hot flashes and another looking at psychologic and physiological hyperarousal in menopausal women with and without sleep disturbance. In 2016, Julie enrolled in a Ph.D. program for clinical psychology at the University of Vermont where she studies mood disorders in adults with a special interest in women's mental health.
Thania was a Clinical Research Coordinator for WHARP from 2013-2015 where she helped to complete recruitment for an NIH R01 grant investigating the effects of hormones on mood in menopause and to launch recruitment for a new study exploring the influence of hot flashes and psychological factors on treatment adherence in breast cancer survivors. In 2015, Thania enrolled in a Ph.D program for child clinical psychology at the University of Denver, where she focuses her research on exploring the cultural and contextual factors that influence mental health needs and service utilization among Latino children. Clinically, she takes a trauma-informed approach to helping youth with internalizing and externalizing disorders.
Semmie Kim was a Clinical Research Coordinator for WHARP from 2013 to 2014, where she worked on NIH-funded investigations studying the effects of new-onset hot flashes in women on their sleep and mood and examining associations between changes in hormones, mood and sleep. After leaving WHARP, Semmie completed her master's degree in epidemiology and health policy from the Mailman School of Public Health at Columbia University. She currently serves as Assistant Director of Research and Evaluation for the Division of Correctional Health Services at New York City Health + Hospitals.